Back to today’s briefing

Story perspectives

Diet and Immunity: Key Drivers of Intestinal Stem Cell Health

10/2/2025

30 6

Summary

Story summary

Diet and immune responses regulate intestinal stem cells, influencing their function.
Calorie intake and fasting impact stem cell activity via mTORC1 signaling and fatty acid oxidation.
Interleukin-22 (IL-22) protects intestinal stem cells from damage and promotes regeneration.
Lgr5 remains a key marker for identifying intestinal and liver stem cells.
Ongoing work examines diet, microbiota, and immune interactions.

1 of 1

Story summary

Diet and immune responses regulate intestinal stem cells, influencing their function.
Calorie intake and fasting impact stem cell activity via mTORC1 signaling and fatty acid oxidation.
Interleukin-22 (IL-22) protects intestinal stem cells from damage and promotes regeneration.
Lgr5 remains a key marker for identifying intestinal and liver stem cells.
Ongoing work examines diet, microbiota, and immune interactions.