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Cancer Cells Amplify Energy Under Mechanical Stress, Study Finds
10/3/2025
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Story summary
- A study in Nature Communications shows cancer cells boost energy output when squeezed.
- Researchers at the Centre for Genomic Regulation in Barcelona found mitochondria deliver ATP to repair DNA under mechanical stress.
- The ATP surge occurs in 84% of confined HeLa cells, forming nucleus-associated mitochondria (NAMs).
- NAMs rise three-fold at invasive fronts versus dense cores in biopsies.
