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New TREM2 Variant Linked to Rapid Alzheimer's in Chinese

10/3/2025

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Summary

Story summary

Hong Kong University of Science and Technology (HKUST) researchers identify the TREM2 H157Y variant linked to Alzheimer's progression in ethnic Chinese.
The variant appears in 1 in 200 Chinese AD patients, five times higher than Europeans.
Carriers may develop severe symptoms within 3–5 years; study calls for a genetic database for ethnic Chinese and notes APOE-?4 as a comparable risk.

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Story summary

Hong Kong University of Science and Technology (HKUST) researchers identify the TREM2 H157Y variant linked to Alzheimer's progression in ethnic Chinese.
The variant appears in 1 in 200 Chinese AD patients, five times higher than Europeans.
Carriers may develop severe symptoms within 3–5 years; study calls for a genetic database for ethnic Chinese and notes APOE-?4 as a comparable risk.