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Exercise Hormone Lac-Phe May Revolutionize Weight Loss

10/4/2025

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Summary

Story summary

Researchers from Baylor College of Medicine and Stanford University report that exercise produces Lac-Phe, which suppresses appetite.
In mice, Lac-Phe reduces appetite, signaling potential weight-loss therapies.
Lac-Phe inhibits AgRP neurons by activating KATP channels, reducing their activity.
The findings appeared in Nature Metabolism on September 16, 2025; future work will test Lac-Phe in humans.

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Story summary

Researchers from Baylor College of Medicine and Stanford University report that exercise produces Lac-Phe, which suppresses appetite.
In mice, Lac-Phe reduces appetite, signaling potential weight-loss therapies.
Lac-Phe inhibits AgRP neurons by activating KATP channels, reducing their activity.
The findings appeared in Nature Metabolism on September 16, 2025; future work will test Lac-Phe in humans.