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New Research Links Protein Glycosylation to Depression Treatment

10/4/2025

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Summary

Story summary

Institute for Basic Science (IBS) researchers link abnormal protein glycosylation to depression.
Chronic stress lowers sialylation in the prefrontal cortex, destabilizing circuits and driving depressive symptoms.
Reducing the enzyme St3gal1 induces depressive-like behaviors in mice and restoring it alleviates them.
Science Advances (October 3, 2025) reports glycosylation as a therapeutic target beyond serotonin, with post-traumatic stress disorder (PTSD) and schizophrenia implications.

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Story summary

Institute for Basic Science (IBS) researchers link abnormal protein glycosylation to depression.
Chronic stress lowers sialylation in the prefrontal cortex, destabilizing circuits and driving depressive symptoms.
Reducing the enzyme St3gal1 induces depressive-like behaviors in mice and restoring it alleviates them.
Science Advances (October 3, 2025) reports glycosylation as a therapeutic target beyond serotonin, with post-traumatic stress disorder (PTSD) and schizophrenia implications.