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New Study Reveals Sigma-A's Continuous Bond with RNA Polymerase

10/4/2025

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Summary

Story summary

New research shows Bacillus subtilis sigma-A remains bound to RNA polymerase during transcription elongation, challenging the idea that sigma factors detach.
In vitro transcription elongation complexes show sigma-A retention at 92-98% across TECs.
In vivo experiments confirmed sigma-A's continuous association with RNAP in living cells.
A region in sigma-70, R1.1, may trigger release, with implications for infection control and biotechnology.

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Story summary

New research shows Bacillus subtilis sigma-A remains bound to RNA polymerase during transcription elongation, challenging the idea that sigma factors detach.
In vitro transcription elongation complexes show sigma-A retention at 92-98% across TECs.
In vivo experiments confirmed sigma-A's continuous association with RNAP in living cells.
A region in sigma-70, R1.1, may trigger release, with implications for infection control and biotechnology.