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New PACE Therapy Offers Hope for Treatment-Resistant Depression

10/4/2025

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Summary

Story summary

A 44-year-old man with treatment-resistant depression found hope through PACE, a new personalized brain stimulation therapy, lasting 30 months.
PACE uses precision brain mapping to tailor stimulation to individual brain patterns, unlike electroconvulsive therapy (ECT).
The targeted atypical salience network (12.4% cortical area) was stimulated. Within seven weeks, suicidal ideation disappeared. Mood rose 59% after four months.

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Story summary

A 44-year-old man with treatment-resistant depression found hope through PACE, a new personalized brain stimulation therapy, lasting 30 months.
PACE uses precision brain mapping to tailor stimulation to individual brain patterns, unlike electroconvulsive therapy (ECT).
The targeted atypical salience network (12.4% cortical area) was stimulated. Within seven weeks, suicidal ideation disappeared. Mood rose 59% after four months.