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New Study Links Obesity and Neuroinflammation to Alzheimer's

10/5/2025

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Summary

Story summary

A study links amyloid beta and neuroinflammation in Alzheimer's via LilrB2.
C4d, a complement cascade molecule, contributes to synapse loss in mice, challenging the view that glial cells are solely responsible.
Led by Carla Shatz, the study was published in Proceedings of the National Academy of Sciences (PNAS); Houston Methodist links obesity to Alzheimer's via extracellular vesicles accelerating plaque buildup.

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Story summary

A study links amyloid beta and neuroinflammation in Alzheimer's via LilrB2.
C4d, a complement cascade molecule, contributes to synapse loss in mice, challenging the view that glial cells are solely responsible.
Led by Carla Shatz, the study was published in Proceedings of the National Academy of Sciences (PNAS); Houston Methodist links obesity to Alzheimer's via extracellular vesicles accelerating plaque buildup.