Back to today’s briefing

Story perspectives

AI-Designed PiggyBac Transposases Outperform Nature in Gene Therapy

10/5/2025

44 6

Summary

Story summary

Researchers from Integra Therapeutics, Pompeu Fabra University, and Centre for Genomic Regulation (CRG) used AI to design synthetic PiggyBac transposases that outperform natural ones.
They screened 31,000 genomes and identified over 13,000 new PiggyBac sequences.
Seven synthetic variants surpassed HyPB in excision activity; Mega-PiggyBac greatly improved DNA integration.
They are FiCAT-compatible; future work will test in animal models.

1 of 1

Story summary

Researchers from Integra Therapeutics, Pompeu Fabra University, and Centre for Genomic Regulation (CRG) used AI to design synthetic PiggyBac transposases that outperform natural ones.
They screened 31,000 genomes and identified over 13,000 new PiggyBac sequences.
Seven synthetic variants surpassed HyPB in excision activity; Mega-PiggyBac greatly improved DNA integration.
They are FiCAT-compatible; future work will test in animal models.