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Study Reveals 2,803 Genes Linked to Aging Neurons

10/7/2025

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Summary

Story summary

Lodato and Weng identified 2,803 age-related genes, with more downregulated than upregulated in aging neurons.
Housekeeping genes tied to cell survival were downregulated, neuron-specific genes remained stable.
Somatic mutations accumulate at 15.1 per neuron annually, with two aging signatures.
Single-cell whole-genome sequencing across ages links somatic mutations to cognitive decline, even without Alzheimer’s.

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Story summary

Lodato and Weng identified 2,803 age-related genes, with more downregulated than upregulated in aging neurons.
Housekeeping genes tied to cell survival were downregulated, neuron-specific genes remained stable.
Somatic mutations accumulate at 15.1 per neuron annually, with two aging signatures.
Single-cell whole-genome sequencing across ages links somatic mutations to cognitive decline, even without Alzheimer’s.