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Story summary
- Glioblastoma (GBM) cells rely on extracellular cholesterol rather than synthesizing it, unlike other brain cells.
- GBM cells with high low-density lipoprotein receptor (LDLR) levels show immune checkpoint expression, suggesting a growth role.
- Mevalonate and other cholesterol intermediates may promote GBM proliferation, highlighting potential therapeutic targets.
- Disrupting lipid rafts in GBM alters signaling and stemness, and therapies remain largely ineffective.
