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Story perspectives

Targeting miR-140-3p Boosts Neuronal Survival in SMA

10/8/2025

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Summary

Story summary

Suppressing miR-140-3p restores KIF5A levels, improves axonal transport, and enhances neuronal survival in SMA.
miR-140-3p targets the motor protein KIF5A, causing its downregulation in SMA.
Advanced imaging confirms that miR-140-3p deregulation disrupts motor-protein function.
miR-140-3p could be a therapeutic target across neurodegenerative diseases; combinatorial treatments and future work should explore other small RNA regulators.

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Story summary

Suppressing miR-140-3p restores KIF5A levels, improves axonal transport, and enhances neuronal survival in SMA.
miR-140-3p targets the motor protein KIF5A, causing its downregulation in SMA.
Advanced imaging confirms that miR-140-3p deregulation disrupts motor-protein function.
miR-140-3p could be a therapeutic target across neurodegenerative diseases; combinatorial treatments and future work should explore other small RNA regulators.