Back to today’s briefing

Story perspectives

Study Links Smoking, Sex to Bladder Mutation Dynamics

10/9/2025

42 5

Summary

Story summary

IRB Barcelona and the University of Washington show smoking and sex shape bladder mutation dynamics in healthy bladder tissue.
Nature published the findings on October 8, 2025.
The study analyzed 45 donor bladder samples using sequencing to detect previously unseen mutations.
Male donors showed greater clonal expansion. Smoking increased mutations in the TERT promoter.

1 of 1

Story summary

IRB Barcelona and the University of Washington show smoking and sex shape bladder mutation dynamics in healthy bladder tissue.
Nature published the findings on October 8, 2025.
The study analyzed 45 donor bladder samples using sequencing to detect previously unseen mutations.
Male donors showed greater clonal expansion. Smoking increased mutations in the TERT promoter.