Back to today’s briefing

Story perspectives

MIT and Harvard Create Revolutionary CAR-NK Cells to Combat Cancer

10/9/2025

50 9

Summary

Story summary

Massachusetts Institute of Technology (MIT) and Harvard University researchers engineered CAR-NK cells to fight cancer, enabling off-the-shelf production and reduced immune rejection.
The study published in Nature Communications shows these CAR-NK cells destroy cancer in humanized mouse models.
The engineering silences HLA class I proteins and adds PD-L1 to limit host attacks.
The CAR-NK cells exhibit reduced cytokine release syndrome.

1 of 1

Story summary

Massachusetts Institute of Technology (MIT) and Harvard University researchers engineered CAR-NK cells to fight cancer, enabling off-the-shelf production and reduced immune rejection.
The study published in Nature Communications shows these CAR-NK cells destroy cancer in humanized mouse models.
The engineering silences HLA class I proteins and adds PD-L1 to limit host attacks.
The CAR-NK cells exhibit reduced cytokine release syndrome.