Story perspectives
Genetics Plays Major Role in ACL Tear Risk
10/9/2025
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Story summary
- A professional football player tore his anterior cruciate ligament (ACL) during a game.
- 23andMe polygenic risk score (PRS) report analyzes genetic factors for ACL tear risk.
- Genetics accounts for 69% of ACL tear risk; variants relate to collagen.
- PRS uses 6,000 variants, not medically validated, with ancestry limitations.
- Preventive steps include strength training, proper technique, and consulting sports professionals.
