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Study: Tramadol and CYP2D6 Inhibitors Heighten Seizure Risk

10/10/2025

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Summary

Story summary

A study finds tramadol with cytochrome P450 2D6 (CYP2D6) inhibitors raises seizure risk in older adults.
The study involved 70,156 nursing home residents aged 65+, with seizures at 18 vs 16 per 100 person-years.
The risk increase with CYP2D6 inhibitors is about 9%.
Tramadol’s chronic-pain benefits may not outweigh the risks; serious adverse events are linked to its use.

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Story summary

A study finds tramadol with cytochrome P450 2D6 (CYP2D6) inhibitors raises seizure risk in older adults.
The study involved 70,156 nursing home residents aged 65+, with seizures at 18 vs 16 per 100 person-years.
The risk increase with CYP2D6 inhibitors is about 9%.
Tramadol’s chronic-pain benefits may not outweigh the risks; serious adverse events are linked to its use.