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Study Reveals How Acidosis Fuels Pancreatic Cancer Growth

10/10/2025

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Summary

Story summary

A study published in Science shows that acidic pH around pancreatic cancer cells accelerates tumor growth and treatment resistance.
Acidosis triggers a metabolic shift from glucose-based energy to mitochondrial respiration, increasing cancer cell survival.
The researchers used CRISPR-Cas9 to identify genes that enable cancer cells to adapt to acidosis, hypoxia, and nutrient deprivation.

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Story summary

A study published in Science shows that acidic pH around pancreatic cancer cells accelerates tumor growth and treatment resistance.
Acidosis triggers a metabolic shift from glucose-based energy to mitochondrial respiration, increasing cancer cell survival.
The researchers used CRISPR-Cas9 to identify genes that enable cancer cells to adapt to acidosis, hypoxia, and nutrient deprivation.