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Ketogenic Diet Boosts Brain Health for APOE4 Carriers

10/10/2025

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Summary

Story summary

University of the Missouri researchers say a ketogenic diet may improve brain energy metabolism and gut health for those at Alzheimer's risk linked to APOE4.
In a mouse study, female APOE4 carriers had healthier gut bacteria and higher brain energy on a ketogenic diet versus high-carb diet.
The diet restored gut diversity and normalized brain metabolites, particularly in female mice.

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Story summary

University of the Missouri researchers say a ketogenic diet may improve brain energy metabolism and gut health for those at Alzheimer's risk linked to APOE4.
In a mouse study, female APOE4 carriers had healthier gut bacteria and higher brain energy on a ketogenic diet versus high-carb diet.
The diet restored gut diversity and normalized brain metabolites, particularly in female mice.