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New MS Research Reveals Target for Potential Treatments

10/11/2025

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Summary

Story summary

Researchers at University of Cambridge have identified disease-associated radial glia-like (DARG) cells linked to chronic inflammation and neurodegeneration in progressive multiple sclerosis.
DARGs occur sixfold more often in progressive MS patients than in healthy individuals.
The cells revert to an early developmental state and show premature aging, releasing inflammatory signals that worsen brain cell damage.
The findings, published in Neuron, suggest targeting DARGs could yield treatments for progressive MS.

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Story summary

Researchers at University of Cambridge have identified disease-associated radial glia-like (DARG) cells linked to chronic inflammation and neurodegeneration in progressive multiple sclerosis.
DARGs occur sixfold more often in progressive MS patients than in healthy individuals.
The cells revert to an early developmental state and show premature aging, releasing inflammatory signals that worsen brain cell damage.
The findings, published in Neuron, suggest targeting DARGs could yield treatments for progressive MS.