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New Study Reveals 30+ Parent-of-Origin Effects on Traits

10/11/2025

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Summary

Story summary

The Hofmeister et al. study presents a method to determine parent-of-origin effects using surrogate parents from large biobanks.
The approach lets researchers infer the parent of origin for alleles without genotype data from both parents.
The study identified over 30 parent-of-origin effects linked to metabolic and growth traits.
The findings imply rare but potentially larger roles for parent-of-origin effects in complex-trait inheritance and growth.

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Story summary

The Hofmeister et al. study presents a method to determine parent-of-origin effects using surrogate parents from large biobanks.
The approach lets researchers infer the parent of origin for alleles without genotype data from both parents.
The study identified over 30 parent-of-origin effects linked to metabolic and growth traits.
The findings imply rare but potentially larger roles for parent-of-origin effects in complex-trait inheritance and growth.