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Study Reveals Biological Basis of Depression in Brain

10/12/2025

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Summary

Story summary

Researchers at McGill University and the Douglas Institute identified changes in excitatory neurons and microglia in depression.
The Nature Genetics study analyzed post-mortem brain tissue from 59 people with depression and 41 without.
Senior author Dr. Gustavo Turecki of McGill University and the Douglas Institute says the findings clarify the biological basis of depression, which affects over 264 million people.

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Story summary

Researchers at McGill University and the Douglas Institute identified changes in excitatory neurons and microglia in depression.
The Nature Genetics study analyzed post-mortem brain tissue from 59 people with depression and 41 without.
Senior author Dr. Gustavo Turecki of McGill University and the Douglas Institute says the findings clarify the biological basis of depression, which affects over 264 million people.