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New SDR-seq Tool Revolutionizes Single-Cell Disease Research

10/13/2025

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Summary

Story summary

European Molecular Biology Laboratory (EMBL) researchers have developed SDR-seq, a new tool that enhances single-cell DNA-RNA sequencing.
SDR-seq analyzes genomic variations and RNA within the same cell, improving accuracy.
The approach targets non-coding DNA regions, where over 95% of disease-related variants occur, enabling study of congenital heart disease and autism.
SDR-seq uses oil-water emulsion droplets to study thousands of cells.
This could enable better diagnostics and treatments for complex diseases.

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Story summary

European Molecular Biology Laboratory (EMBL) researchers have developed SDR-seq, a new tool that enhances single-cell DNA-RNA sequencing.
SDR-seq analyzes genomic variations and RNA within the same cell, improving accuracy.
The approach targets non-coding DNA regions, where over 95% of disease-related variants occur, enabling study of congenital heart disease and autism.
SDR-seq uses oil-water emulsion droplets to study thousands of cells.
This could enable better diagnostics and treatments for complex diseases.