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Study Links Omeprazole Use to 70% Higher Migraine Risk

10/13/2025

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Summary

Story summary

A UK study published in Neurology Clinical Practice links omeprazole use to a 70% higher risk of migraines.
Users of proton pump inhibitors (PPIs) experienced migraines at 25%, compared with 19% of non-users.
The study indicates an association and does not confirm a direct causal link.
Experts urge patients to consult their doctors before changing PPIs because of ongoing warnings about long-term use.

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Story summary

A UK study published in Neurology Clinical Practice links omeprazole use to a 70% higher risk of migraines.
Users of proton pump inhibitors (PPIs) experienced migraines at 25%, compared with 19% of non-users.
The study indicates an association and does not confirm a direct causal link.
Experts urge patients to consult their doctors before changing PPIs because of ongoing warnings about long-term use.