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Study Links Overactive AMPA Receptors to Long COVID Brain Fog

10/15/2025

Summary

Story summary

Researchers at Yokohama City University linked an overactive AMPA receptor to Long COVID brain fog.
A PET imaging study showed higher AMPA receptor levels in memory- and attention-related regions.
The hyperactivity may stem from inflammation caused by COVID-19, contributing to cognitive symptoms.
The findings point to potential treatments, including existing medications such as perampanel.
Experts caution that further research with larger populations is needed to confirm results and assess efficacy.

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Story summary

Researchers at Yokohama City University linked an overactive AMPA receptor to Long COVID brain fog.
A PET imaging study showed higher AMPA receptor levels in memory- and attention-related regions.
The hyperactivity may stem from inflammation caused by COVID-19, contributing to cognitive symptoms.
The findings point to potential treatments, including existing medications such as perampanel.
Experts caution that further research with larger populations is needed to confirm results and assess efficacy.