Story perspectives

New Neuron Discovery Offers Hope for Chronic Pain Relief

10/15/2025

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Summary

Story summary

Researchers led by J. Nicholas Betley (lead researcher) identify Y1 receptor neurons in the lateral parabrachial nucleus that can reduce chronic pain.
These neurons balance pain with survival needs such as hunger and fear.
The neurons remain active during chronic pain, suggesting they can override pain signals when other needs arise.
The study, published in Nature, indicates targeting these neurons could yield new treatments and support behavioral interventions.

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Story summary

Researchers led by J. Nicholas Betley (lead researcher) identify Y1 receptor neurons in the lateral parabrachial nucleus that can reduce chronic pain.
These neurons balance pain with survival needs such as hunger and fear.
The neurons remain active during chronic pain, suggesting they can override pain signals when other needs arise.
The study, published in Nature, indicates targeting these neurons could yield new treatments and support behavioral interventions.