Story perspectives

FGF21 and GDF15: Key Links Between Metabolism and Mental Health

10/15/2025

Summary

Story summary

Fibroblast growth factor 21 (FGF21) is a regulator of metabolism and stress, with biomarker potential for mitochondrial disorders.
FGF21 levels are linked to depression and obesity, signaling a complex metabolism–mental health relationship.
The energetic stress marker GDF15 is a dynamic biomarker correlating with disease severity and psychosocial stress.
Together these findings highlight FGF21 and GDF15 in understanding metabolic and psychological health.

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Story summary

Fibroblast growth factor 21 (FGF21) is a regulator of metabolism and stress, with biomarker potential for mitochondrial disorders.
FGF21 levels are linked to depression and obesity, signaling a complex metabolism–mental health relationship.
The energetic stress marker GDF15 is a dynamic biomarker correlating with disease severity and psychosocial stress.
Together these findings highlight FGF21 and GDF15 in understanding metabolic and psychological health.