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Major Study Confirms mRNA Vaccine Safety in Early Pregnancy

10/16/2025

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Summary

Story summary

A large French study found no increased risk of major congenital malformations (MCMs) in infants when mothers received mRNA vaccines in the first trimester.
The study analyzed data from over 530,000 infants, reporting 176.6 MCMs per 10,000 vaccinated versus 179.4 per 10,000 unvaccinated.
Published in JAMA Network Open, the study reinforces prior vaccine-safety findings; experts urge updating guidelines, noting the scope is limited to the first trimester.

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Story summary

A large French study found no increased risk of major congenital malformations (MCMs) in infants when mothers received mRNA vaccines in the first trimester.
The study analyzed data from over 530,000 infants, reporting 176.6 MCMs per 10,000 vaccinated versus 179.4 per 10,000 unvaccinated.
Published in JAMA Network Open, the study reinforces prior vaccine-safety findings; experts urge updating guidelines, noting the scope is limited to the first trimester.