Story perspectives

New Method Preserves Brain Function During Cancer Treatment

10/16/2025

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Summary

Story summary

Researchers at the University of California, Irvine, led by Munjal Acharya, developed a method to protect cognitive function during cranial radiation therapy for brain cancer by inhibiting C5a receptor 1 (C5aR1).
They used genetic and pharmacological approaches to block C5aR1.
In mice, blocking C5aR1 preserved cognitive function and did not reduce radiation's anticancer effect.
PMX205 is safe for humans and shows promise for future clinical applications.

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Story summary

Researchers at the University of California, Irvine, led by Munjal Acharya, developed a method to protect cognitive function during cranial radiation therapy for brain cancer by inhibiting C5a receptor 1 (C5aR1).
They used genetic and pharmacological approaches to block C5aR1.
In mice, blocking C5aR1 preserved cognitive function and did not reduce radiation's anticancer effect.
PMX205 is safe for humans and shows promise for future clinical applications.