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Living Brain Tissue Reveals Surprising Differences, Affects Therapy

10/17/2025

Summary

Story summary

Mount Sinai's Living Brain Project reports that living brain tissue differs from postmortem tissue, with over 60% of proteins and 95% of RNA transcripts processed differently.
Researchers based their analysis on samples taken from living patients during deep brain stimulation surgeries.
The findings challenge assumptions about brain biology and underscore the need for living-tissue studies to inform neuroscience.
Deep brain stimulation findings could enable personalized therapies for neurological disorders.

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Story summary

Mount Sinai's Living Brain Project reports that living brain tissue differs from postmortem tissue, with over 60% of proteins and 95% of RNA transcripts processed differently.
Researchers based their analysis on samples taken from living patients during deep brain stimulation surgeries.
The findings challenge assumptions about brain biology and underscore the need for living-tissue studies to inform neuroscience.
Deep brain stimulation findings could enable personalized therapies for neurological disorders.