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California Reports First Locally Acquired Severe Mpox Cases

10/17/2025

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Summary

Story summary

California confirms the first U.S. case of a severe mpox strain in a resident with no travel history.
Long Beach resident is recovering at home after hospitalization.
A second case in Los Angeles County marks the nation’s first locally acquired mpox case of clade I.
Clade I is more severe than clade II, linked to the 2022-23 outbreak.
The JYNNEOS vaccine is the sole preventive measure in the United States.

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Story summary

California confirms the first U.S. case of a severe mpox strain in a resident with no travel history.
Long Beach resident is recovering at home after hospitalization.
A second case in Los Angeles County marks the nation’s first locally acquired mpox case of clade I.
Clade I is more severe than clade II, linked to the 2022-23 outbreak.
The JYNNEOS vaccine is the sole preventive measure in the United States.