Story perspectives

Study Links HLA Alleles to Early-Onset Lung Issues

10/17/2025

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Summary

Story summary

The study analyzed 31 patients with early-onset symptoms or situs inversus to assess cystic fibrosis (CF) and primary ciliary dyskinesia (PCD).
Seven patients in the cohort had early-onset productive coughs.
One patient carried pathogenic CFTR variants.
In Vietnam, the study found associations between specific HLA alleles and extensive bronchiectasis and bronchiolitis (BL/BE).
No significant associations were found between CFTR variants and the studied groups.

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Story summary

The study analyzed 31 patients with early-onset symptoms or situs inversus to assess cystic fibrosis (CF) and primary ciliary dyskinesia (PCD).
Seven patients in the cohort had early-onset productive coughs.
One patient carried pathogenic CFTR variants.
In Vietnam, the study found associations between specific HLA alleles and extensive bronchiectasis and bronchiolitis (BL/BE).
No significant associations were found between CFTR variants and the studied groups.