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New Virus Modifications Enhance Cancer Vaccine Effectiveness

10/18/2025

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Story summary
  • Université de Montréal (UdeM) researchers modified vesicular stomatitis virus to boost cancer vaccine effectiveness in mice.
  • The study in Journal for Immunotherapy of Cancer shows modified virus elicits a stronger response against melanoma.
  • Columbia Engineering (Columbia University) researchers developed Trojan Horse-style therapy using bacteria to deliver viruses to tumors, evading defenses.
  • Findings were published in Nature Biomedical Engineering and show a method for targeting solid tumors while controlling viral spread.