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Midnight Wakefulness Harms Brain, Increases Risk Factors

10/20/2025

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Story summary
  • Harvard Medical School and Massachusetts General Hospital researchers report that staying awake after midnight harms brain function, labeling Mind After Midnight.
  • Dr. Elizabeth Klerman of Harvard Medical School and Massachusetts General Hospital says circadian rhythms push the brain into survival mode at night.
  • The shift increases risks of binge eating, addiction relapse, and suicide, three times more likely between midnight and 6 a.m.