Back to today’s briefing

Story perspectives

Multiple Sclerosis May Damage Brain Years Before Symptoms

10/21/2025

34 3

Summary

Story summary

Researchers at UC San Francisco found that multiple sclerosis begins damaging the brain up to seven years before symptoms appear, after analyzing 5,000+ blood proteins from 134 individuals.
They detected early signs of myelin damage marked by spikes in myelin oligodendrocyte glycoprotein (MOG) and neurofilament light chain, with interleukin-3 (IL-3) playing a crucial role.
The findings were published in Nature Medicine.

1 of 1

Story summary

Researchers at UC San Francisco found that multiple sclerosis begins damaging the brain up to seven years before symptoms appear, after analyzing 5,000+ blood proteins from 134 individuals.
They detected early signs of myelin damage marked by spikes in myelin oligodendrocyte glycoprotein (MOG) and neurofilament light chain, with interleukin-3 (IL-3) playing a crucial role.
The findings were published in Nature Medicine.