Story perspectives

Genetic Markers Link Inflammation to Depression Subtypes

10/21/2025

Summary

Story summary

Researchers at Kore University of Enna, Italy, led by Prof. Alessandro Serretti, identified a genetic inflammatory signature linked to depression subtypes.
The study analyzed 1,059 European patients with major depressive disorder.
Higher polygenic scores for C-reactive protein correlated with symptoms and treatment outcomes, with treatment-resistant patients scoring highest.
The findings, published in Genomic Psychiatry, support personalized mental health approaches using genetic and inflammatory markers and call for studies across populations.

1 of 1

Story summary

Researchers at Kore University of Enna, Italy, led by Prof. Alessandro Serretti, identified a genetic inflammatory signature linked to depression subtypes.
The study analyzed 1,059 European patients with major depressive disorder.
Higher polygenic scores for C-reactive protein correlated with symptoms and treatment outcomes, with treatment-resistant patients scoring highest.
The findings, published in Genomic Psychiatry, support personalized mental health approaches using genetic and inflammatory markers and call for studies across populations.