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Study Reveals Hormone Therapy Alters Proteins in Trans Women

10/21/2025

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Summary

Story summary

A study from the Murdoch Children's Research Institute in Victoria, Australia, of 40 transgender women, found that gender-affirming hormone therapy changes protein levels in adult transgender women.
After six months, 36 of the 100 sex-differentiated proteins showed significant changes.
Protein changes may affect health, increasing autoimmune risk and reducing heart disease risk.
The findings were published in Nature Medicine, with researchers calling for more long-term health studies.

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Story summary

A study from the Murdoch Children's Research Institute in Victoria, Australia, of 40 transgender women, found that gender-affirming hormone therapy changes protein levels in adult transgender women.
After six months, 36 of the 100 sex-differentiated proteins showed significant changes.
Protein changes may affect health, increasing autoimmune risk and reducing heart disease risk.
The findings were published in Nature Medicine, with researchers calling for more long-term health studies.