Story perspectives

Semaglutide Shows Heart Health Benefits Beyond Weight Loss

10/23/2025

Summary

Story summary

A University College London study of 17,604 participants aged 45 and older finds cardiovascular benefits from semaglutide, the active ingredient in Wegovy and Ozempic, independent of weight loss.
A reduction in waist circumference accounts for about one-third of these benefits.
Experts say semaglutide may also lower inflammation and improve vessel health.
The findings show benefits extend to people with BMI 27.
More research is needed to understand the mechanisms.

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Story summary

A University College London study of 17,604 participants aged 45 and older finds cardiovascular benefits from semaglutide, the active ingredient in Wegovy and Ozempic, independent of weight loss.
A reduction in waist circumference accounts for about one-third of these benefits.
Experts say semaglutide may also lower inflammation and improve vessel health.
The findings show benefits extend to people with BMI 27.
More research is needed to understand the mechanisms.