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New Therapy Offers Statin-Free Solution for Cholesterol Management

10/24/2025

Summary

Researchers Develop Cholesterol Therapy

Researchers from the University of Barcelona and the University of Oregon developed a therapy using polypurine hairpins (PPRHs) to regulate cholesterol by targeting PCSK9.
In genetically modified mice, a single injection of the therapy significantly reduced PCSK9 and cholesterol levels.
The study was published in Biochemical Pharmacology.
The researchers say the approach could offer a statin-free alternative for managing hypercholesterolemia and avoid side effects common with traditional medications.

Summary

Researchers Lower Dementia Risk

A meta-analysis involving nearly one million participants suggests that lowering cholesterol may reduce dementia risk.
Researchers from the University of Bristol and Copenhagen University Hospital used genetic variants to mimic statin effects.
They found that individuals with these variants had a lower risk of developing dementia.
The study, published in Alzheimer's & Dementia, urges randomized trials to test long-term cognitive effects of cholesterol-lowering drugs.

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Researchers Develop Cholesterol Therapy

Researchers from the University of Barcelona and the University of Oregon developed a therapy using polypurine hairpins (PPRHs) to regulate cholesterol by targeting PCSK9.
In genetically modified mice, a single injection of the therapy significantly reduced PCSK9 and cholesterol levels.
The study was published in Biochemical Pharmacology.
The researchers say the approach could offer a statin-free alternative for managing hypercholesterolemia and avoid side effects common with traditional medications.

1 / 2