Story perspectives

New Review Reveals Antidepressants' Varied Health Impacts

10/26/2025

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Summary

Story summary

The Lancet published a systematic review analyzing the physiological effects of antidepressants, drawing on 151 studies and 58,534 participants.
The review found significant differences among antidepressants in weight gain, blood pressure, and heart rate.
For example, agomelatine is linked to weight loss in 55% of users, while maprotiline causes weight gain in 48.1%.
The findings support personalized treatment plans, especially since depression often coexists with other health issues.

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Story summary

The Lancet published a systematic review analyzing the physiological effects of antidepressants, drawing on 151 studies and 58,534 participants.
The review found significant differences among antidepressants in weight gain, blood pressure, and heart rate.
For example, agomelatine is linked to weight loss in 55% of users, while maprotiline causes weight gain in 48.1%.
The findings support personalized treatment plans, especially since depression often coexists with other health issues.