Story perspectives
Psychedelics Boost Brain Connections, Offering Hope for Depression
10/28/2025
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Story summary
- Pavel Ortinski of the University of Kentucky led research showing psychedelic drugs strengthen connections in the claustrum.
- The study shows psychedelics reverse synaptic plasticity from long-term depression to long-term potentiation in claustrum neurons projecting to the anterior cingulate cortex.
- This change may explain vivid memories from psychedelic experiences and suggest potential treatments for depression and anxiety.
