Story perspectives

Ketamine Infusions Show No Benefit for Severe Depression

10/29/2025

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Summary

Story summary

The Dublin, Ireland trial, published in JAMA Psychiatry, found that repeated intravenous ketamine infusions added to standard care did not improve outcomes for hospitalized patients with severe depression.
The study enrolled 65 participants and compared ketamine with an active placebo, midazolam.
Results showed no statistically significant difference in depression scores between groups.
Ketamine had a slightly higher remission rate, but the difference was not robust.

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Story summary

The Dublin, Ireland trial, published in JAMA Psychiatry, found that repeated intravenous ketamine infusions added to standard care did not improve outcomes for hospitalized patients with severe depression.
The study enrolled 65 participants and compared ketamine with an active placebo, midazolam.
Results showed no statistically significant difference in depression scores between groups.
Ketamine had a slightly higher remission rate, but the difference was not robust.