Story perspectives

Study Reveals Gene Link to Women's MS Risk

10/30/2025

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Summary

Story summary

A study finds the X-linked gene KDM6A is more active in women, which may explain the higher incidence of multiple sclerosis (MS) in women.
In female mice, disabling KDM6A improved mobility and reduced nerve damage compared with mice carrying an active gene.
Metformin reduced brain inflammation in female mice, suggesting sex-specific treatments may be needed.
Further studies must explore blocking KDM6A and the hormone-inflammation link after menopause.

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Story summary

A study finds the X-linked gene KDM6A is more active in women, which may explain the higher incidence of multiple sclerosis (MS) in women.
In female mice, disabling KDM6A improved mobility and reduced nerve damage compared with mice carrying an active gene.
Metformin reduced brain inflammation in female mice, suggesting sex-specific treatments may be needed.
Further studies must explore blocking KDM6A and the hormone-inflammation link after menopause.