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New Study Links 13 Genes to Severe Obesity Risk

10/30/2025

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Summary

Story summary

A study by The Pennsylvania State University (Penn State) identified 13 obesity-related genes from 850,000 individuals across six continents.
Five genes including YLPM1, RIF1, GIGYF1, SLC5A3, and GRM7 were newly linked to obesity, tripling the risk of severe obesity.
The study emphasizes cross-ancestry value, as prior work focused on European populations and may miss non-European factors.
The findings could advance precision medicine by informing future treatments for obesity-related diseases.

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Story summary

A study by The Pennsylvania State University (Penn State) identified 13 obesity-related genes from 850,000 individuals across six continents.
Five genes including YLPM1, RIF1, GIGYF1, SLC5A3, and GRM7 were newly linked to obesity, tripling the risk of severe obesity.
The study emphasizes cross-ancestry value, as prior work focused on European populations and may miss non-European factors.
The findings could advance precision medicine by informing future treatments for obesity-related diseases.