Story perspectives

Melatonin Use Linked to 90% Increased Heart Failure Risk

11/5/2025

Summary

Story summary

A preliminary study by the American Heart Association indicates that long-term melatonin supplement use may significantly increase heart failure risk.
The study analyzed health records of over 130,000 adults with insomnia, finding that users of melatonin for at least a year had a 90% higher chance of heart failure compared to non-users.
Melatonin users were nearly 3.5 times more likely to be hospitalized for heart failure and almost twice as likely to die from any cause during a five-year follow-up.
Experts caution that these findings raise safety concerns but do not establish a direct cause-and-effect relationship, highlighting the need for further research.

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Story summary

A preliminary study by the American Heart Association indicates that long-term melatonin supplement use may significantly increase heart failure risk.
The study analyzed health records of over 130,000 adults with insomnia, finding that users of melatonin for at least a year had a 90% higher chance of heart failure compared to non-users.
Melatonin users were nearly 3.5 times more likely to be hospitalized for heart failure and almost twice as likely to die from any cause during a five-year follow-up.
Experts caution that these findings raise safety concerns but do not establish a direct cause-and-effect relationship, highlighting the need for further research.