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AI Reveals Genetic Links to Corpus Callosum Size and Disorders

11/5/2025

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Summary

Story summary

Researchers at the Mark and Mary Stevens Neuroimaging and Informatics Institute mapped the genetic architecture of the corpus callosum using AI and MRI data from over 50,000 individuals.
They identified numerous genes that influence the corpus callosum’s size and thickness.
Many of these genes are active during prenatal development.
The findings reveal genetic overlaps with ADHD and bipolar disorder, indicating a link between genetic variation and neuropsychiatric disorders.
The team has made its AI tool publicly available to facilitate further research.

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Story summary

Researchers at the Mark and Mary Stevens Neuroimaging and Informatics Institute mapped the genetic architecture of the corpus callosum using AI and MRI data from over 50,000 individuals.
They identified numerous genes that influence the corpus callosum’s size and thickness.
Many of these genes are active during prenatal development.
The findings reveal genetic overlaps with ADHD and bipolar disorder, indicating a link between genetic variation and neuropsychiatric disorders.
The team has made its AI tool publicly available to facilitate further research.