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Story perspectives

Bowel Cancer Breakthrough: Immune Evasion and New Treatments

11/6/2025

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Story summary
  • Nature reports a 'big bang' moment in bowel cancer when cancer cells evade the immune system.
  • This immune escape helps explain why immunotherapy works for only about 15% of patients.
  • The study of 29 patients highlights the potential of combining immunotherapy with epigenome-modifying drugs.
  • Researchers aim to develop personalized treatment plans and improve early detection, noting that over half of UK bowel cancer cases are preventable.