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Story summary
- Nutritional epigenetics shows maternal diet shapes fetal gene expression and lifelong risk for metabolic, neurodevelopmental, and immune diseases.
- DNA methylation is modulated by maternal nutrients such as folate and choline.
- Maternal undernutrition or overnutrition can disrupt insulin signaling and lipid metabolism in offspring.
- The placenta mediates these effects.
- Future clinical approaches may involve targeted nutritional interventions during the periconception period to improve child health outcomes.
