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Study Links Low Choline Levels to Anxiety Disorders

11/10/2025

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Summary

Story summary

Researchers at UC Davis Health report that people with anxiety disorders have 8% lower brain choline levels than those without anxiety, based on 25 studies totaling 370 anxious and 342 non-anxious, and published in Molecular Psychiatry.
The findings implicate low choline levels in the prefrontal cortex for emotion and behavior.
The researchers urge Americans to meet daily choline needs.
They caution against self-medicating with supplements and support a balanced diet.

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Story summary

Researchers at UC Davis Health report that people with anxiety disorders have 8% lower brain choline levels than those without anxiety, based on 25 studies totaling 370 anxious and 342 non-anxious, and published in Molecular Psychiatry.
The findings implicate low choline levels in the prefrontal cortex for emotion and behavior.
The researchers urge Americans to meet daily choline needs.
They caution against self-medicating with supplements and support a balanced diet.