Story perspectives
Weekly Estradiol Injections Cut Testosterone in 29 Patients
11/13/2025
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Story summary
- The Journal of the Endocrine Society reports weekly injectable estradiol for hormone replacement therapy reduces testosterone in 29 patients over 15 months.
- Testosterone levels fell even as the average dose declined from 4.3 mg to 3.7 mg.
- Spironolactone did not lower testosterone levels and may decrease estradiol levels in the study.
