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Genetics Key to Early-Onset Depression, Study Reveals

11/13/2025

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Summary

Story summary

Karolinska Institutet researchers report that early-onset depression (before age 25) has a stronger genetic component than late-onset depression (after age 50) in a study of more than 150,000 individuals.
The study identified twelve genomic regions linked to early-onset depression, indicating distinct biological pathways.
Columbia University and McGill University researchers report that SGK1 protein levels are linked to depression in those who faced childhood trauma and propose SGK1 inhibitors.

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Story summary

Karolinska Institutet researchers report that early-onset depression (before age 25) has a stronger genetic component than late-onset depression (after age 50) in a study of more than 150,000 individuals.
The study identified twelve genomic regions linked to early-onset depression, indicating distinct biological pathways.
Columbia University and McGill University researchers report that SGK1 protein levels are linked to depression in those who faced childhood trauma and propose SGK1 inhibitors.